Combination of M2e peptide with stalk HA epitopes of influenza A virus enhances protective properties of recombinant vaccine.
Identifieur interne : 000212 ( Main/Exploration ); précédent : 000211; suivant : 000213Combination of M2e peptide with stalk HA epitopes of influenza A virus enhances protective properties of recombinant vaccine.
Auteurs : Liudmila M. Tsybalova [Russie] ; Liudmila A. Stepanova [Russie] ; Marina A. Shuklina [Russie] ; Eugenia S. Mardanova [Russie] ; Roman Y. Kotlyarov [Russie] ; Marina V. Potapchuk [Russie] ; Sergei A. Petrov [Russie] ; Elena A. Blokhina [Russie] ; Nikolai V. Ravin [Russie]Source :
- PloS one [ 1932-6203 ] ; 2018.
Descripteurs français
- KwdFr :
- Animaux, Femelle, Glycoprotéine hémagglutinine du virus influenza (immunologie), Glycoprotéine hémagglutinine du virus influenza (pharmacologie), Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (immunologie), Peptides (immunologie), Peptides (pharmacologie), Souris, Souris de lignée BALB C, Vaccins antigrippaux (immunologie), Vaccins antigrippaux (pharmacologie), Virus de la grippe A (immunologie), Épitopes (immunologie), Épitopes (pharmacologie).
- MESH :
- immunologie : Glycoprotéine hémagglutinine du virus influenza, Infections à Orthomyxoviridae, Peptides, Vaccins antigrippaux, Virus de la grippe A, Épitopes.
- pharmacologie : Glycoprotéine hémagglutinine du virus influenza, Peptides, Vaccins antigrippaux, Épitopes.
- Animaux, Femelle, Infections à Orthomyxoviridae, Souris, Souris de lignée BALB C.
English descriptors
- KwdEn :
- Animals, Epitopes (immunology), Epitopes (pharmacology), Female, Hemagglutinin Glycoproteins, Influenza Virus (immunology), Hemagglutinin Glycoproteins, Influenza Virus (pharmacology), Influenza A virus (immunology), Influenza Vaccines (immunology), Influenza Vaccines (pharmacology), Mice, Mice, Inbred BALB C, Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (prevention & control), Peptides (immunology), Peptides (pharmacology).
- MESH :
- chemical , immunology : Epitopes, Hemagglutinin Glycoproteins, Influenza Virus, Influenza Vaccines, Peptides.
- chemical , pharmacology : Epitopes, Hemagglutinin Glycoproteins, Influenza Virus, Influenza Vaccines, Peptides.
- immunology : Influenza A virus, Orthomyxoviridae Infections.
- prevention & control : Orthomyxoviridae Infections.
- Animals, Female, Mice, Mice, Inbred BALB C.
Abstract
Influenza infection could be more effectively controlled if a multi-purpose vaccine with the ability to induce responses against most, or all, influenza A subtypes could be generated. Conserved viral proteins are a promising basis for the creation of a broadly protective vaccine. In the present study, the immunogenicity and protective properties of three recombinant proteins (vaccine candidates), comprising conserved viral proteins fused with bacterial flagellin, were compared.
DOI: 10.1371/journal.pone.0201429
PubMed: 30138320
Affiliations:
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Le document en format XML
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Tsybalova</name><affiliation wicri:level="1"><nlm:affiliation>Department of Vaccinology, Smorodintsev Research Institute of Influenza, Ministry of Health of the Russian Federation, St. Petersburg, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Vaccinology, Smorodintsev Research Institute of Influenza, Ministry of Health of the Russian Federation, St. Petersburg</wicri:regionArea><wicri:noRegion>St. Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Stepanova, Liudmila A" sort="Stepanova, Liudmila A" uniqKey="Stepanova L" first="Liudmila A" last="Stepanova">Liudmila A. Stepanova</name><affiliation wicri:level="1"><nlm:affiliation>Department of Vaccinology, Smorodintsev Research Institute of Influenza, Ministry of Health of the Russian Federation, St. Petersburg, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Vaccinology, Smorodintsev Research Institute of Influenza, Ministry of Health of the Russian Federation, St. Petersburg</wicri:regionArea><wicri:noRegion>St. Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Shuklina, Marina A" sort="Shuklina, Marina A" uniqKey="Shuklina M" first="Marina A" last="Shuklina">Marina A. 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Kotlyarov</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Bioengineering, Research Center of Biotechnology, Russian Academy of Sciences, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Institute of Bioengineering, Research Center of Biotechnology, Russian Academy of Sciences, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Potapchuk, Marina V" sort="Potapchuk, Marina V" uniqKey="Potapchuk M" first="Marina V" last="Potapchuk">Marina V. Potapchuk</name><affiliation wicri:level="1"><nlm:affiliation>Department of Vaccinology, Smorodintsev Research Institute of Influenza, Ministry of Health of the Russian Federation, St. Petersburg, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Vaccinology, Smorodintsev Research Institute of Influenza, Ministry of Health of the Russian Federation, St. Petersburg</wicri:regionArea><wicri:noRegion>St. Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Petrov, Sergei A" sort="Petrov, Sergei A" uniqKey="Petrov S" first="Sergei A" last="Petrov">Sergei A. Petrov</name><affiliation wicri:level="1"><nlm:affiliation>Department of Vaccinology, Smorodintsev Research Institute of Influenza, Ministry of Health of the Russian Federation, St. Petersburg, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Vaccinology, Smorodintsev Research Institute of Influenza, Ministry of Health of the Russian Federation, St. Petersburg</wicri:regionArea><wicri:noRegion>St. Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Blokhina, Elena A" sort="Blokhina, Elena A" uniqKey="Blokhina E" first="Elena A" last="Blokhina">Elena A. Blokhina</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Bioengineering, Research Center of Biotechnology, Russian Academy of Sciences, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Institute of Bioengineering, Research Center of Biotechnology, Russian Academy of Sciences, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Ravin, Nikolai V" sort="Ravin, Nikolai V" uniqKey="Ravin N" first="Nikolai V" last="Ravin">Nikolai V. Ravin</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Bioengineering, Research Center of Biotechnology, Russian Academy of Sciences, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Institute of Bioengineering, Research Center of Biotechnology, Russian Academy of Sciences, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Epitopes (immunology)</term><term>Epitopes (pharmacology)</term><term>Female</term><term>Hemagglutinin Glycoproteins, Influenza Virus (immunology)</term><term>Hemagglutinin Glycoproteins, Influenza Virus (pharmacology)</term><term>Influenza A virus (immunology)</term><term>Influenza Vaccines (immunology)</term><term>Influenza Vaccines (pharmacology)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Orthomyxoviridae Infections (immunology)</term><term>Orthomyxoviridae Infections (prevention & control)</term><term>Peptides (immunology)</term><term>Peptides (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Glycoprotéine hémagglutinine du virus influenza (immunologie)</term><term>Glycoprotéine hémagglutinine du virus influenza (pharmacologie)</term><term>Infections à Orthomyxoviridae ()</term><term>Infections à Orthomyxoviridae (immunologie)</term><term>Peptides (immunologie)</term><term>Peptides (pharmacologie)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Vaccins antigrippaux (immunologie)</term><term>Vaccins antigrippaux (pharmacologie)</term><term>Virus de la grippe A (immunologie)</term><term>Épitopes (immunologie)</term><term>Épitopes (pharmacologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Epitopes</term><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Influenza Vaccines</term><term>Peptides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Epitopes</term><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Influenza Vaccines</term><term>Peptides</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Infections à Orthomyxoviridae</term><term>Peptides</term><term>Vaccins antigrippaux</term><term>Virus de la grippe A</term><term>Épitopes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Peptides</term><term>Vaccins antigrippaux</term><term>Épitopes</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Mice</term><term>Mice, Inbred BALB C</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Infections à Orthomyxoviridae</term><term>Souris</term><term>Souris de lignée BALB C</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Influenza infection could be more effectively controlled if a multi-purpose vaccine with the ability to induce responses against most, or all, influenza A subtypes could be generated. Conserved viral proteins are a promising basis for the creation of a broadly protective vaccine. In the present study, the immunogenicity and protective properties of three recombinant proteins (vaccine candidates), comprising conserved viral proteins fused with bacterial flagellin, were compared.</div></front></TEI><affiliations><list><country><li>Russie</li></country><region><li>District fédéral central</li></region><settlement><li>Moscou</li></settlement></list><tree><country name="Russie"><noRegion><name sortKey="Tsybalova, Liudmila M" sort="Tsybalova, Liudmila M" uniqKey="Tsybalova L" first="Liudmila M" last="Tsybalova">Liudmila M. Tsybalova</name></noRegion><name sortKey="Blokhina, Elena A" sort="Blokhina, Elena A" uniqKey="Blokhina E" first="Elena A" last="Blokhina">Elena A. Blokhina</name><name sortKey="Kotlyarov, Roman Y" sort="Kotlyarov, Roman Y" uniqKey="Kotlyarov R" first="Roman Y" last="Kotlyarov">Roman Y. Kotlyarov</name><name sortKey="Mardanova, Eugenia S" sort="Mardanova, Eugenia S" uniqKey="Mardanova E" first="Eugenia S" last="Mardanova">Eugenia S. Mardanova</name><name sortKey="Petrov, Sergei A" sort="Petrov, Sergei A" uniqKey="Petrov S" first="Sergei A" last="Petrov">Sergei A. Petrov</name><name sortKey="Potapchuk, Marina V" sort="Potapchuk, Marina V" uniqKey="Potapchuk M" first="Marina V" last="Potapchuk">Marina V. Potapchuk</name><name sortKey="Ravin, Nikolai V" sort="Ravin, Nikolai V" uniqKey="Ravin N" first="Nikolai V" last="Ravin">Nikolai V. Ravin</name><name sortKey="Shuklina, Marina A" sort="Shuklina, Marina A" uniqKey="Shuklina M" first="Marina A" last="Shuklina">Marina A. Shuklina</name><name sortKey="Stepanova, Liudmila A" sort="Stepanova, Liudmila A" uniqKey="Stepanova L" first="Liudmila A" last="Stepanova">Liudmila A. Stepanova</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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